Formulation and Evaluation of SR Tablets of Anti-diabetic drug Gliclazide
نویسندگان
چکیده
منابع مشابه
Formulation and Evaluation of Chondroitin Sulphate Tablets of Aceclofenac for Colon Targeted Drug Delivery
The aim of the present study was to develop a single unit, site-specific matrix tablets of aceclofenac allowing targeted drug release in the colon with a microbially degradable polymeric carrier, chondroitin suphate (CS) and to coat the optimized batches with a pH dependent polymeric. The tablets were prepared by wet granulation method using starch mucilage as a binding agent and HPMC K-100 ...
متن کاملPharmacokinetics and Pharmacodynamics of Gliclazide from Immediate and Modified Release Formulation Tablets in Rats
The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...
متن کاملPharmacokinetics and Pharmacodynamics of Gliclazide from Immediate and Modified Release Formulation Tablets in Rats
The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...
متن کاملFormulation and Evaluation of Chondroitin Sulphate Tablets of Aceclofenac for Colon Targeted Drug Delivery
The aim of the present study was to develop a single unit, site-specific matrix tablets of aceclofenac allowing targeted drug release in the colon with a microbially degradable polymeric carrier, chondroitin suphate (CS) and to coat the optimized batches with a pH dependent polymeric. The tablets were prepared by wet granulation method using starch mucilage as a binding agent and HPMC K-100 ...
متن کاملFormulation and Invitro Evaluation of Hydrogel Matrices of Gliclazide Modified Release Tablets
The work aimed at developing a modified release hydrogel formulation of poorly soluble drug, Gliclazide using a retardant hydrophilic polymer HPMC in two grades i.e., HPMC 15 cps and Methocel K4M. All six formulations were developed and evaluated for the in-vitro drug release up to 16hrs and compared with that of the marketed formulation. GMF VI was found to have similar release pattern proving...
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ژورنال
عنوان ژورنال: American Journal of PharmTech Research
سال: 2019
ISSN: 2249-3387
DOI: 10.46624/ajptr.2019.v9.i3.001